References

1. IMS PharmaTrend® monthly, section MAT 03/2015.
2. IMS MIDAS data, section MAT 12/2012.
3. If you take a prescription or non-prescription medication for a health condition, always talk to your pharmacist about interactions before choosing any cough or cold product.
4. Helixia® Cough Prospan® and Helixia® Cough Prospan® for Kids Packaging Inserts. PENDOPHARM, Division of Pharmascience Inc., June 2012
5. Helixia® Sinus 200 mg and Helixia® Sinus 100 mg for Kids Packaging Inserts. PENDOPHARM, Division of Pharmascience Inc., June 2012.
6. Data on file, Engelhard Arzneimittel GmbH & Co. KG.
7. Data on file, MCM Klosterfrau Vertriebs GmbH.
8. Marketed as Soledum.
9. Contains sorbitol as a sugar substitute.
10. Pseudoephedrine in adults, Benylin®, and Robitussin® Drug Monographs. Canadian Pharmacists Association. Compendium of Pharmaceuticals and Specialties. Accessed July 3 and July 12, 2013.
11. May not be suitable for everyone. Always read the label and follow the directions of use.
12. May not be suitable for everyone. Always read the label and follow the directions of use. A healthcare professional should be consulted before use of Helixia® Cough Prospan® in infants under 1 year of age or if use exceeds 7 days.
13. Does not contain honey.
14. Health Canada Releases Decision on the Labelling of Cough and Cold Products for Children (archived), available at: http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/13267a-eng.php. Accessed October 5, 2015.
15. IMS Knowledge Link, R05C (Expectorants), MAT 12, 2010 and 2012.
16. Gulyas A, et al. [Consequent therapy of chronic obstructive respiratory tract illnesses in children.] Atemw-Lungenkrkh 1997;23(5):291-4. German.
17. Meyer-Wegener J, et al. [Ivy versus ambroxol in chronic bronchitis]. Z Allg Med 1993;69(3):61-6. German.
18. Mansfeld HJ, et al. [Clinical study: Treatment of children with chronic obstructive airways disease with Prospan®]. TW Pädiatrie 1997;10(3):155 7. German.
19. Mansfeld HJ, et al. [Therapy of bronchial asthma with dried ivy leaf extract]. MMW 1998;140(3):26-30. German.
20. Maidannik V, et al. [Efficacy of Prospan® application in children’s diseases of respiratory tract]. Ped Toc Gyn 2003;4:1-7. German.
21. Bolbot Y, et al. [Comparing the efficacy and safety of high-concentrate (5-7.5:1) ivy leaves extract and acetylcysteine for treatment of children with acute bronchitis]. Drugs of Ukraine Nov 2004. German.
22. Internal data. Prospan® cough syrup vs. placebo in South Korea. 2000.
23. Runkel, Prenner, Häberlein. An article on the mechanism of action of ivy. Pharm. Ztg. 2005.
24. Tesche, Metternich, Sonnemann, Engelke, Dethlefsen. The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Eur. Arch. Otorhinolaryngol 2008.
25. Kehrl, Sonnemann, Dethlefsen. Therapy for acute nonpurulent rhinosinusitis with cineole: results of a double-blind, randomized, placebo-controlled trial. The Laryngoscope 2004.
26. http://www.prospan.de/en/about-prospan#dnn_ctr1523_ModuleContent